Description
Buy 5 Meo DMT
5-Methoxy-N,N-dimethyltryptamine (also known as 5-MeO-DMT) is a naturally-occurring psychedelic substance of the tryptamine class. It is structurally related to DMT and 5-HO-DMT (bufotenine) and is reputed to produce the most powerful and intense psychedelic states within the entire class. 5-MeO-DMT produces its effects by binding to serotonin receptors in the brain, although the precise mechanism is not known.
It is distributed in a wide variety of plant species as well as in the venom of a single toad species (Bufo Alvaris). Although little is known about its history, it is believed to have been used in South American shamanic practices for centuries.In modern times, both the extracts of the toad venom as well as synthetic powder form are used, primarily via vaporization.
The synthesis and psychoactive effects were documented by Alexander Shulgin in his 1997 book TiHKAL (“Tryptamines I Have Known and Loved”). Recent studies have demonstrated its capacity to induce mystical experiences and there is growing interest in exploring its potential therapeutic effects.
Subjective effects include unity and interconnectedness, time distortion, conceptual thinking, euphoria, and ego loss. 5-MeO-DMT’s psychedelic effects are best compared to DMT in terms of intensity (extreme) and duration (very short). However, it generally lacks a visual geometry component and tends to produce more physical euphoria as well as even stronger transpersonal or mystical-like effects (e.g. ego loss) than DMT.
Additionally, both mental and physical side effects are reported to occur more often with 5-MeO-DMT. These effects include significant anxiety and dysphoria as well as nausea and bodily discomfort, and are often described as challenging and overwhelming.
Unlike DMT, which has been shown to possess minimal physiological toxicity, 5-MeO-DMT’s safety profile is much less established. A small number of deaths have been linked to its use and appear to be a result of physical overdose. Some reports suggest it may cause serotonin toxicity when combined with certain substances such as MAOIs; it may also have cardiotoxic properties.
Anecdotal reports suggest that this substance is only suitable for users with extensive experience with powerful psychedelics (e.g. DMT, ayahuasca, and DPT) and trained in their safe use. It is highly advised to use harm reduction practices if using this substance.
5-Meo-DMT’s psychedelic effects are primarily believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Specifically, this molecule shows high binding affinity for the 5-HT2A and 5-HT1A subtypes.However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be involved to an extent. This can result in 5-MeO-DMT becoming dangerously toxic when combined with MAOIs, RIMAs, SSRIs, stimulants or any substance which acts as a releasing agent or reuptake inhibitor of monoamine neurotransmitters.
5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenin
